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So, it may not be a Botticelli...Really valuable paintings are securely crated with enough padding to ensure stability, and then moved on 'air ride' suspension

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

systems. Sometimes meters are employed to log severe bumps. Very expensive insurance protects the movers against the worst scenarios. This insurance can only be

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

obtained because insurers are satisfied that the safest techniques are being used. The expense will reflect the value of the piece.

There is a point when alth

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ugh your picture is valuable, it is not worth quite so much fuss...even though damage is unthinkable.

It might be a family heirloom which you may want to take

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

personal responsibility for, in the course of moving house.

You need to consider the three areas of danger:

1) Damage to the frame from bumping
2) Flakin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

old paint from bumping
3) Spearing the picture itself (often by bumping and so breaking the picture glass)

The frame can sometimes be the most valuable

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

part of a picture. Wooden frames are easy to protect with padded paper, but plaster frames require much more attention.

One way to properly pack a plaster fram

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e is to measure it, and source or cut, 2 pieces of cheap plywood board measuring 10cm wider and longer than the frame (giving 5cm overlap at each side).

These

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

re the 'sacrificial' boards...The ones that can take the knocks. You have to ensure that the picture, placed squarely in the middle, can neither move off the ed

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ge of the board, nor suffer from knocks... either in handling or from bumps on the van. You will place the frame... centred...on the middle of the board, and th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n use bubble wrap to stop it moving off the edge of the plywood...where it can be damaged.

1) Lay out two lengths of tie measuring x3 the width of the picture.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Mover’s web tie is best (or goes to your local sewing shop and get 1 inch hem liner as a substitute).

2) Lay on top some 3 ply movers paper... a heavy blanke

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t, though not perfect, will do if need be

3) Lay out (30cm wide) bubble wrap around the 4 edges of the paper, two pieces thick. There will be 8 pieces in all.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

4) Place the ply wood board onto the bubble wrap / paper.

5) Place the picture frame squarely onto the board.

6) Fold the shortest sides of the wrapping over

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the picture (you now have bubble-wrap protecting the under and top edges of the sides)

7) Place an equal sized piece of plywood on top of the picture... Kept o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

f the picture by the thick wrapping you have just folded over the sides.

8) Fold up the long sides of the paper, from top and bottom and secure with parcel tap

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e.

9) Take up the ties, make a loop in one end, pass the other end through it, and tie it off, putting minimal pressure on the package. The bubble wrap will gi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ve anti slip qualities to the package, but the pressure should just very slightly compress the package...and so ensure that the picture frame cannot move down b

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tween the plywood when the package is stood up.

So...You will need: Ties, wrapping Paper, plywood boards (or flattened cardboard boxes...according to your budg

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

et), parcel tape and bubble wrap.

When you have finished, you should be able to feel confident that the package is both shock proof, and protected from ripping

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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