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San Jose is the oldest city in city in California, rich in heritage with racial diversity and economic opportunities. Families heading to San Jose are finding out why the city is considered fun.

San Jose is a sprawling

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

175 square miles located in northern California. The third-largest city in the state with over 912,000 residents, it is the eleventh largest in the nation. San Jose is in the Santa Clara Valley with city neighbors Buen

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Vista and Burbank nearby. After a 14.2% increase in population between 1990 and 2000, the number of people heading to San Jose has slowed in recent years. According to the U.S. Census Bureau in 2005, the median age of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ity residents was 34.7 years. Three parts nearly make the whole population for San Jose with 32% of White non-Hispanic, 32% Asian and 31% Hispanic races. The average of 3.1 people per home found families accounting for

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

73% of city households. English was not the language of choice in 55% of city homes, as 38% of the citizenry is foreign-born.

San Jose residents enjoy low unemployment and poverty while earnings are among the best in C

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lifornia. People heading to San Jose are finding well paying jobs with a median household income of $70,921 in 2005. Among the most common occupations are management, professional, and related occupations making up 40%

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

f the work force. Poverty was three percent below the national average in 2005 at 10%, only 4.9% for White Non-Hispanic residents. Agriculture is a large part of the city's economy, with wine production and food process

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ing and distribution among the leading industries. But it's technology that has made San Jose what it is today. At the heart of the Silicon Valley, known for its prominence in semiconductor and computer-related technolo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y, is some industry giants. Businesses like Adobe Systems, Cisco and eBay have headquarters in San Jose. Hewlett-Packard, IBM and Hitachi also have bases in the city.

San Jose has some high property values that have ri

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

en greatly since 2000 when the median home was tagged at a value of $427,800. That number crept up to 625,400 in 2005, but a very modest increase in a state with surging home values. New home construction is in decline.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

The number of building permits has dwindled from 2329 buildings built in 1997 to 602 in 2006. Home ownership in San Jose is high for California with 62% of homes occupied by owners. The average age of city dwellings is

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

below the state average with 18% of housing units built since 1990. The median monthly housing costs for mortgaged owners was $2,409, non-mortgaged owners $439, and renters $1,153.

For a city of its size, San Jose is o

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e of the safest places to live in America. It was ranked #1 among big cities by Morgan Quitno three years in a row. Stolen car reports, however, have been on the rise, from 2,615 thefts in 1999 to over 5,500 in 2005. Th

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

FBI Crime Rate dropped during that period to 236.8. The U.S. average is 325.2. Higher than the national average is 36% of citizens who hold a bachelor's degree or higher in San Jose. One big college in the city is San

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Jose State University with its full-time enrollment of 20,861 students. Heading to San Jose for its climate might be a good choice. Residents enjoy mild but semi-arid weather with about 15 inches of annual precipitation

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

The average temperature in January is 48.7 while July sees high temperatures averaging 84 degrees. With 300 sunny days per year, the average annual temperature is 70 degrees.

Named the third Most Fun City in America b

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Cranium Inc., San Jose is just 20 minutes away from some popular beaches on the Pacific Ocean. Nearby Santa Cruz is a popular hangout for surfers. Residents can also access nearby mountain ranges for summer hiking and

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

winter skiing. The city is a short distance from some top-notch golf courses, including renowned Pebble Beach. One major sports franchise, the NHL’s San Jose Sharks makes their home on the ice at HP Pavilion, known as t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e “Shark Tank.” Public transportation is seldom used by people who commute to work. A whopping 78% of workers drove to work alone in 2005, while 3% used mass transit. Among those who commuted to work, it took an average

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

of 25 minutes to get to their jobs. Three international airports in the area with Norman Y. Mineta San Jose International the closest, followed by airports in Oakland and San Francisco. San Jose is also served by Amtrak

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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TBI is more than twice as likely in males. The highest incidence is among persons 15 to 24 years of age and 75 years and older. Given the large toll of TBI and absence of a cure, prevention is of paramount importance.

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