Answers - Real Estate

When we move, we generally focus on the residence, the neighborhood, taxes, schools, and the like. There are occasions, though, when we want something specific in a location. Recently,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

one of our visitors asked for help finding a locale with very specific and unique attributes.

She and her husband live in southern California and wanted to move somewhere less expens

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ive, near woodlands, not too hot, not too cold, and not too much snow. Seems like looking for a needle in the haystack, right? Not necessarily--thanks to all of the data available on t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e web.

We broke the request into three components: cost of living, climate, and forest cover.

Determining the cost of living for all locales across the state could b

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e very complicated, so we made some simplifying assumptions. First, housing, food, and energy costs account for most of the average household budget. Second, food and energy costs tend

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

to be consistent across regions. That left us with housing costs.

We then broke down housing costs into its major components: mortgage/rent and property taxes. The US

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Census collects housing value and property tax data as part of their decennial survey, so we decided to use that data to calculate a housing cost index by county. The results were int

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

resting. While California as whole is one of the most expensive states, we found a lot of variance in housing cost by county within the state.

Based on our calculations, Modo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

c, Kern, and Kings Counties were the least expensive. Marin, San Francisco, and Santa Cruz Counties had the highest housing costs. In general, northern counties not on the coast were l

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

oking most affordable.

So far, so good...at least we could recommend less expensive areas. Now, how to find areas with moderate temperatures?

NOAA (National Oceanic and Atmospheric A

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

dministration--the branch of government that includes the National Weather Service) provides maps of "Heating Degree Days" and "Cooling Degree Days". Exactly, what are "Heating Degree

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Days" and "Cooling Degree Days"?

One heating degree day occurs for each degree the daily mean temperature is below 65 degrees Fahrenheit. So if the average temperature is 63 on a part

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

cular day, that's two Heating Degree Days (2 degrees multiplied by 1 day). It indicates fuel consumption to heat your residence.

One cooling degree day occurs for each degree the dail

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

y mean temperature is above 65 degrees Fahrenheit. So if the average temperature is 67 on a particular day, that's two Cooling Degree Days (2 degrees multiplied by 1 day). It indicates

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

electricity consumption to cool your residence.

So all we had to do was compare those two maps with our housing cost map to find areas that weren't too hot, weren't too cold, and were

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n't too expensive. Heating degree days are at moderate levels in the central valley and along the central coast. Cooling degree days are at moderate levels in the northern half of the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

tate. Putting it all together, we were now focused on a few counties: Shasta, Tehama, Glenn, and Colusa.

Step two complete.

Next, we turned to the US Geological Survey for a forest c

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

over map of California. Each of those counties had areas of forest cover, specifically pine, fir, spruce, and hardwood. Comparing the forestry map with the other three maps allowed us

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

o identify areas within each county that would meet their needs. The western sections of Colusa and Glenn counties; the east and west ends of Tehama county; and everywhere except the s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

outh-central area of Shasta county.

Problem solved. Knowing what areas would meet their general needs, they could now focus on finding the best place to live in any one of those areas

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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