Answers - Real Estate

Right behind the dikes in Holland you will find fields with tulips, windmills and farmers on wooden shoes. R

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

eally? No, this is how Holland, also called The Netherlands, looked like 100 years ago. Nowadays, this small

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

kingdom is no.6 of the best European economies, but more important, Holland is the most densly populated coun

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

try in Europe(number 7 in the world), with over 480 inhabitans per km2. And the number of inhabitants is sti

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

l rising. Now, you don't have to be a professor in real-estate to understand that an investment in land could

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

be very interesting.

Even better, an investment in (Hol)land is a very safe, solid and tax-free investment,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

because of the following reasons;

* Holland is the most densly populated country in Europe (number 7 in the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

world and almost twice as densed as the UK). Average land prices have been risen over 200% in the last 10 yea

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rs. And as the demand of land will continue in the next decades the land prices will continue to rise as well

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

* All plots will be transferred by a solicitor/notary. The whole purchase process is almost identical to th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

one in the UK. This means 100% security.

* Your land can not be stolen, forged or go bankrupt.

* A possibl

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e future gain on the sale of your plot is completely tax-free, as Holland does not know Capital Gains Tax!.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

o, what this really means to you, is that you can acquire an investment that gives you these important aspect

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s. So, you don’t have to worry if the stock markets go down, like in 2001. And, on top of that it can give yo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

an extra super return on investment as soon as a project will be bought by the project-developpers/construc

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ors, which is purely a matter of when, not if. In that case you will get a “buy-out” price for your land. And

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

than you can count on a price that is about 50% to 700% higher than your investment. Most important questio

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

for any investor:What can I lose? Well, practically nothing, as land prices will continue to go up (with let

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

's say min. 3% per year) in our densly populated country you would still make a profitable r.o.i. and.... tax

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

free.

Holland-Banking (www.holland-banking) is the company that can help you making an investment in Holland

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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You've worked your way up throughout your career, attaining a high-level rank through demonstrated achievement, dedication, and proficiency. One day, you find yourself needing to look elsewhere, and that's where the old nagging doubt sets in - you never finished (or even started) college. What if this holds you back?

You can have dozens of marvelous ideas to get free publicity, but nothing will happen unless you pick up the phone and call a reporter. But what to say?

If there's a product, there's a market! Any business can work with the same product or service you deal in, many may be doing right now, why not your business! Your business reflects you. There are people in the market who need your offer. Re-organize your business activities and be back to do the business building basics again. 90 percent of your business time and efforts should be dedicated to it.

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Answers - Holland; Europe's Hong-Kong

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