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As we mature as a species, most people realize we need to take care of our world. That being said, most people think doing so is expensive. So, what does

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

green construction cost?

The cost of green construction is a rather complex subject. It is an easily misunderstood subject also. One reason for this is t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he idea of an integrated approach that considers the economic benefits of any green project in relationship to the cost. The up front costs of a project m

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ay be higher. Yet, these costs are often balanced against the long term low operating costs of the building. It is further complicated by the fact that ma

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ny of the benefits of the green approach cannot be easily expressed in dollar and cents. If our personal environment is safer and cleaner, and our health

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

is better as a result, how do we quantify this?

In one example cost study done in California, $1578 was added to the cost of a home in order to bring it

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to a minimal green construction level. The additional costs went into projects that made the home more energy efficient. The estimate was that at current

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

energy costs, the savings would be $185 per year. The initial cost would be amortized over the length of an 8 percent mortgage, and this would yield an ad

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ditional cost of $139 a year. So, the net result would really be a savings of $46 dollars per year. It is how one prefers to look at this example that the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

y would answer the question of cost. One approach claims the green construction improvements cost over fifteen hundred dollars. Another approach claims th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

at the green improvements actually save over forty dollars per year. It is all a matter of perspective.

Most experts agree that green construction cost r

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

anges from nothing at all to a nominal cost. It is possible to go to the next level and increase costs by using exotic items in the building plan. In most

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

cases, this is not done, and the cost of the green structure does not differ much from the cost of the traditional building. Most builders are trying to

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

do the right thing today anyway. Even when they do not consider what they are doing as green, they still try to do the right thing. They also have some ve

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ry strict codes they must follow.

It is hard to compare recent projects. Green construction planners do not normally do cost estimates on their jobs comp

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

aring traditional costs. Traditional planners do not usually do cost estimates on green construction costs for their projects. In a recent study of 33 pro

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

perties in California that did compare costs, the cost of going green was about 2 percent higher. This amounted to about $3 to $5 per square foot.

Green

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

construction might very well be the wave of the future. Many new projects take years from the initial planning to the completion of construction. It is li

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

kely that code changes, and customer demands will change over the next few years. What would be the cost of scrapping a construction project and starting

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

over again? Green construction costs little, and sometime even saves. It is the wave of the future though, and the bigger cost might come from ignoring it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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