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After a six-week stalemate, the spot uranium price indicator renewed its upward climb, as witnessed by the weekly spot

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

uranium price change announced by UxC on January 29th and by Trade Tech’s Nuclear Market Review in the magazine’s mon

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

th end report on January 31st. Both consulting services increased the uranium price indicator by $3 to US$75/pound U3O

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

8 by month end.

TradeTech reported extremely low transaction volume for the first month of 2007. Only one spot transa

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ction was reported – a modest quantify of less than 5,000 pounds U3O8 equivalent. According to Nuclear Market Review e

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ditor Treva Klingbiel, “The discretionary nature of about 50 percent of this demand has created an impasse between buy

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ers and sellers. While some buyers have increased the price they are willing to pay, in an effort to solicit firm pric

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e offers, sellers remain entrenched in their position that prices will continue to rise in the future. As a result, a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

significant gap still exists between willing buyers and willing sellers.”

Many market participants took a breather af

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ter the record price rise in mid December. TradeTech Chief Executive Gene Clark told StockInterview, “The large demand

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

from discretionary buyers removed a strong ‘must buy’ component from the market and caused a sharp drop in January’s

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

transaction volume. Thus, the gap that previously existed between buyers and sellers widened.” But Clark warned, “We e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

xpect uranium prices to regain upward momentum in February.” Utilities may be paying higher prices for nuclear fuel as

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

the year goes on.

By comparison, UF6 suppliers have shown a willingness to hold prices in order to try to conclude t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ransactions. As a result, TradeTech’s UF6 price indicator held steady during January at $199.00 per kgU as UF6 product

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. UF6 is uranium hexafluoride, the chemical form of uranium used during the enrichment process. UF6 consists of one ur

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

anium atom combined with six fluorine atoms.

The spot UF6 conversion price fell in Europe during January, dropping be

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

low the North American price to $11.15 per kgU for the first time since these markets diverged in the year 2000. This

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is the cost of converting U3O8 to UF6. Sales of the conversion component of some UF6 inventory were to blame. Some swa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Answers - Expect Higher Uranium Prices in February (and Later)

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