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Three years ago, one could only find Cameco Corp (CCJ) trading on the New York Stock exchange. As of late November 2006, Energy Metals Corp (EMU) began trading on the NYSE ARCA. Energy Metals is currently developing their Texas uranium in situ recovery mine for producti

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

on in either late 2007 or early 2008.

One tier down on the American Stock Exchange is the Fronteer Group (FRG), which is a hybrid gold company holding uranium-mineralized assets. A recent entry to the American exchange is first pure-play uranium company to trade on thi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s exchange: Uranerz Energy (URZ). Uranerz is now the second publicly traded company, after Cameco Corp, in which investors can also trade stock options. The announcement was made at the end of January.

After those, there are a number of different companies with some pr

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ospects better than others. However, before reviewing those, let’s look at what could well become the world’s second largest uranium company, by market capitalization, after Cameco Corp. On early Monday morning, Canada’s Globe and Mail newspaper published a report that

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Johannesburg- and Toronto-listed SXR Uranium One (TSX: SXR) planned to acquire TSX- and AIM-listed UrAsia Energy (TSX: UUU) for approximately $3 billion. In what has been announced as a friendly take-over, SXR Uranium One plans to issue some $3.1 billion in stock to buy

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

UrAsia. Before the announcement, SXR was valued at less than CDN$2 billion.

In previous interviews with SXR Uranium One chief executive Neal Froneman, he has repeatedly told us he wishes to list on a U.S. stock exchange. If and when the acquisition closes – it was ann

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ounced that it should by mid May of this year – the new Uranium One would hold uranium properties on four continents: Africa, Australia, Asia and North America. SXR’s Dominion uranium mine should begin producing this March. UrAsia Energy is currently producing in Kazakh

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

stan. SXR’s Australian ‘Honeymoon’ in situ leach uranium operation is scheduled to start producing in early 2008.

According to Canada’s national newspaper, the combined companies have the potential to annually produce some 19 million pounds by 2012. That’s about what C

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ameco Corp’s Cigar Lake was expected to produce before the mine flooded this past October. Since then, Cameco has delayed in announcing when the company believes its uranium mine will actually be in shape to produce uranium.

Based upon our conversations with Neal Frone

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

man, and in light of this new business combination creating the world’s second largest uranium mining company, it shouldn’t be too far into the future when Uranium One announces it plans to list on the New York Stock Exchange. The headline of their February 12th news re

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

lease announced, “Uranium One and UrAsia Energy Announce Combination to Create Emerging Senior Uranium Company.” Aside from Cameco Corp, there really is no other senior pure play uranium company.

As for the rest of the companies now trading on the over the counter bull

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

etin board, we have reviewed two which offer hope to investors. Uranium Energy (OTC BB: URME) plans to mine uranium using the in situ recovery (ISR) method. Chief operating officer Harry Anthony appears to be one of the boys in the ISR club with decades of experience be

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

hind him. He lives and works in south Texas.

After extensive interviews with Mr. Anthony – which we used in our publication “Investing in the Great Uranium Bull Market” in explaining the ISR method of mining – it became evident to us that if Anthony couldn’t get an ISR

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

operation functioning in Texas, that no one else on the planet was likely to do so. From what we understand, Uranium Energy could be producing uranium by 2009 on its Goliad property.

Another newcomer seems to be doing very well, Yellowcake Mining (OTCBB: YCKM). While

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

it appears to be a ‘new company,’ the company’s property is not. Yellowcake Mining acquired the Juniper Ridge (Wyoming) property from powerhouse Strathmore Minerals (TSX: STM; OTC: STHJF) on January 30th. Previous drilling through 1979 outlined up to 15 million pounds

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of uranium. Plans were made in that year to build a 2000-ton/day mill. But, that was the year when uranium demand fell off, and the mill was never built. With the uranium price continuing to head higher, Yellowcake Mining stands to benefit from uranium-friendly Wyoming

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

and some of Strathmore Mineral’s expertise in the form of David Miller.

There are two other major uranium companies, both with market capitalizations in excess of C$1 billion: Denison Mines (TSX: DML) and Paladin Resources (TSX: PDN). Both are producing uranium compani

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

es and highly respected in many circles for their separate achievements. The business combination of International Uranium Corporation and Denison Mines has gone smoothly so far. Dissatisfied with producing in just Namibia, Paladin now hopes to mine uranium elsewhere in

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Africa and possibly in Australia. Both foreign companies could be candidates for future U.S. stock exchange listings.

In 2006, uranium prices nearly doubled. While 2007 has seen uranium slowly creep higher – now at US$75/pound, many analysts believe uranium could trad

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e above US$100/pound before this year ends. If that’s the case, then we might expect a number of uranium companies pursuing a listing on either the New York or American stock exchanges over the next few years.

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tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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