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BALTIMORE, MD-Uranium and zinc remain my top base metal picks for investors in 2007, despite a recent 15% decline in zinc prices on rising inventories. And I believe that it's a good thi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ng we've established an early position in Firestone Ventures (TSX-V: FV), because they have both.

Firestone Ventures has completed the first 21 core drill holes of the winter 2006/2007

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

drill campaign at their Torlon Hill zinc project.

A total of 938 meters in 21 vertical holes were drilled during November and December, with hole depths ranging from 21.3 meters to 96.0 meters.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

So far, the drill core mineralogy encountered is consistent with mineralized zones defined during the previous drill campaign, which averaged about 8% zinc over various depths.

Highlights of t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e drilling to date include:

* Ten of the completed holes (TH06-25, 26, 29 through TH06-36) are step-out holes, drilled at 25 to 50 meter spacing and extending 150 meters northwest of previous d

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rilling

* Nine drill holes (TH06-24, 27, 28, 37 through 42) are in-fill holes within the area of high-grade zinc mineralization defined by the previous drill campaign. Previous holes in this ar

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

a include TH06-02 (33.0 meters of 22% zinc, including 17.1 meters of 31.9% zinc) and TH06-05 (39.5 meters of 5.7% zinc)

* Drill holes TH06-23 and TH06-43 are step-out holes 25 meters east of Ho

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

le TH06-02 and 40 meters east of TH06-13

The drill program is still on hiatus for the holidays but should resume any day now. The next phase will consist of in-fill and step-out drilling to the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

southwest to test a newly identified zone of lead, zinc and silver within the Cinco Hermanos underground workings. The last phase of drilling will consist of step-out holes towards the west, tar

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

geting reported zinc mineralization at the La Canada adits.

Firestone Ventures is currently reviewing the 2,200 meter program and says it is considering expanding it to further define the miner

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

lization.

Over 3,000 miles away, Firestone recently signed a letter of intent with Marum Resources Inc. (TSX-V: MMU) to acquire all of Marum's metallic and industrial minerals permits in southw

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

estern Alberta. The four permits cover 249,872 acres of uranium property near the town of Fort Macleod and bring Firestone's total land package in the area to 354,735 acres-over 24 times the siz

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

of Manhattan.

Upon signing of a formal agreement, Marum will retain a 10% carried interest in the acquired permits for ten years. But get this . . .

Firestone acquired these permits for a mer

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e $3,000!

Now, you might be thinking that because Firestone picked up the permits for next to nothing, the mineralization on the property must be substandard. But that's just not the case.

Dur

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ng the early 80s, rock samples collected south of Fort Macleod were found to contain ore-grade uranium concentrations (up to 0.2% U3O8, or approximately 4 pounds per ton) in the same type of roc

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ks and in the same roll-front form that characterize the major deposits of Wyoming that have produced over 200 million pounds of uranium.

In the event that an economic deposit is developed, the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

southern Alberta roll-front uranium appears to occur in a form that can be processed by in-situ leaching (ISL). This means that the uranium can be solution-mined using injection and production w

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ells rather than being excavated with open pits or underground mining. The ISL process is simple, uses local groundwater that is naturally enriched in uranium and returns purified, less-radioact

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ve water to the environment, meaning the fish in the area are not likely to grow a third eye. In fact, there is virtually no land disturbance and the process does not require waste or tailings f

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

acilities.

Firestone Ventures (TSX-V: FV) remains listed as a buy on weakness on the Gold World portfolio. I recommend waiting for a slip below $0.50 before adding to or establishing a position

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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