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To understand economic indicators, we must understand the ways in which economic indicators differ. There are three major attributes each economic indicator has: Rela

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tion to the Business Cycle / Economy Economic Indicators can have one of three different relationships to the economy: Procyclic: A procyclic (or procyclical) economi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

indicator is one that moves in the same direction as the economy. So if the economy is doing well, this number is usually increasing, whereas if we're in a recession thi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

indicator is decreasing. The Gross Domestic Product (GDP) is an example of a procyclic economic indicator. Countercyclic: A countercyclic (or countercyclical) economic

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

indicator is one that moves in the opposite direction as the economy. The unemployment rate gets larger as the economy gets worse so it is a countercyclic economic indica

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tor. Acyclic: An acyclic economic indicator is one that has no relation to the health of the economy and is generally of little use. The number of home runs the Montrea

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Expos hit in a year generally has no relationship to the health of the economy, so we could say it is an acyclic economic indicator. Frequency of the Data In most coun

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ries GDP figures are released quarterly (every three months) while the unemployment rate is released monthly. Some economic indicators, such as the Dow Jones Index, are a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ailable immediately and change every minute. Timing Economic Indicators can be leading, lagging, or coincident which indicates the timing of their changes relative to

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

how the economy as a whole changes. Leading: Leading economic indicators are indicators which change before the economy changes. Stock market returns are a leading in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

icator, as the stock market usually begins to decline before the economy declines and they improve before the economy begins to pull out of a recession. Leading economic

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ndicators are the most important type for investors as they help predict what the economy will be like in the future. Lagged: A lagged economic indicator is one that do

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s not change direction until a few quarters after the economy does. The unemployment rate is a lagged economic indicator as unemployment tends to increase for 2 or 3 quar

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ters after the economy starts to improve. Coincident: A coincident economic indicator is one that simply moves at the same time the economy does. The Gross Domestic Pro

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

uct is a coincident indicator.

List of Economic Indicators Gross Domestic Product (GDP) (nominal and real) (for the entire nation or per individual) Index of Leading

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ndicators Gross national happiness (GNH), a new concept relating happiness with economic growth Population Labor Force: Employment rate, Average Weekly earnings Publi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Expenditure, Revenues, Budget Surplus and Deficit, National Debt Personal Income, Expenditure, Savings International: Balance of Payments & Balance of Trade Productiv

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ity Survey Manufacturing output, Capacity Utilization, Inventories Money Supply, Interest Rates, Yield on various financial Instruments and Yield Curves. Stock Market

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Indices Inflation, CPI, Producer Price Index New Home Sales Retail Sales, Auto Sales Lagging indicator, a historical indicator following an event which reacts slowly t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

economic changes Genuine Progress Indicator, a concept in green economics and welfare economics that has been suggested as a replacement metric for gross domestic produc

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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